If you are an adult cigarette smoker who has tried and failed to quit using FDA-approved methods (NRT, bupropion, varenicline), the Cochrane evidence supports considering nicotine e-cigarettes as an additional tool. Here is what the evidence suggests works best:

• Use a nicotine-containing device — the evidence is clear that nicotine vapes outperform non-nicotine vapes for cessation
• Pair vaping with structured support — quit rates are highest when vapes are used alongside counseling or quit-line support, not as a standalone purchase
• Set a quit date and transition plan — the studies that show the best results use vaping as a short-to-medium-term bridge, not an indefinite replacement
• Monitor your cigarette consumption — the goal is reduction to zero combustible cigarettes; if you are still smoking daily after 4–6 weeks, the approach may not be working for you
• For PMTA-aware product options, see our best refillable pod vape systems comparison for devices with clear regulatory status
• Research FDA-compliant vape juices and e-liquids that meet regulatory standards
• Consult your healthcare provider — especially if you have cardiovascular conditions, are pregnant, or are taking medications affected by nicotine