A lot of shop owners assume that once they register with the FDA, they're good to go anywhere in the US. That's not how it works. The FDA's tobacco retailer registration is a federal requirement, but it doesn't replace state or local licenses. Each state has its own tobacco control board or revenue department that issues retail licenses, and many cities and counties add their own layer.

For example, some states require a separate vapor product retailer license, while others treat vape shops under general tobacco licenses. Your local city might have zoning rules that restrict where a vape shop can open. So, the FDA registration is just one piece of the puzzle.