Date	Event	Significance
2020	JUUL submits original PMTAs for its first-generation device and pods	Entry into federal review
June 2022	FDA issues Marketing Denial Orders (MDOs) for original JUUL products, citing insufficient toxicological evidence	Near-market exit
June 2022	FDA places MDOs under administrative stay less than two weeks later for additional review	Temporary reprieve
June 2024	FDA rescinds MDOs, returns applications to substantive review, citing new case law	Reversal
July 2023	JUUL submits first JUUL2 PMTA (device + Virginia Tobacco pod at 18 mg/mL)	Next-gen filing begins
December 2023	JUUL submits JUUL2 menthol pod PMTA at 18 mg/mL	Menthol filing
May 2026	FDA authorizes 4 Glas pods including mango and blueberry — first non-tobacco/menthol flavors	Flavor precedent
July 2025	FDA authorizes 5 original JUUL products (device + tobacco/menthol pods at 3% and 5%)	Original JUUL returns
Aug 4–21, 2026	FDA authorizes 4 additional on! pouches and 11 ZYN ULTRA pouches	Pouch acceleration
Aug 27, 2026	FDA issues MGOs for 3 JUUL2 products (orders issued)	JUUL2 authorized
Aug 28, 2026	FDA publicly announces JUUL2 authorization; total authorized e-cigarettes reaches 48	Official announcement