Pennsylvania Act 57, signed by Governor Josh Shapiro in December 2025, establishes a mandatory state registry for all electronic nicotine delivery systems (ENDS). The law puts the Office of the Attorney General in charge of approving which vape manufacturers, brands, and flavors can be sold legally in the state pennsylvania vape registry law act 57.

To appear on the approved directory, a manufacturer must have marketed its products in the United States as of August 8, 2016, and submitted a product review to the FDA on or before September 9, 2020. This effectively limits the legal market to products with federal PMTA applications already under review or authorized pa s new vaping law takes effect oct 17 what consumers retailers need to know.

The bill's sponsor, State Representative Jeanne McNeill (D-Lehigh), said the measure is designed "to protect kids, support law-abiding retailers, and crack down on illegal vapor products." It passed the state House with bipartisan support, 147-56 .

Attorney General Dave Sunday confirmed that enforcement begins October 19 with targeted inspections of vape wholesalers and retailers across the state pennsylvania vape product directory enforcement begins october 19.